Mentatcurated
▸ Concept

De-extinction

The project of reviving extinct species by reconstructing their genomes and growing viable embryos — using living relatives as the genomic and reproductive scaffold.

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In a nutshell

De-extinction starts with the genome of a target species, assembled from ancient DNA or inferred by comparing close living relatives. Researchers then edit a living relative's genome toward the target sequence — CRISPR is the main tool — and implant the resulting embryo into a surrogate to gestate. No method produces a perfect replica; the result is a hybrid organism carrying key traits of the extinct species. The hard part is threefold: ancient DNA degrades and is never complete; editing hundreds of loci simultaneously is error-prone; and surrogate gestation outside the original species has rarely worked at scale.

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